Billye served as editor of publications for Kenneth Hagin Ministries from 1970 to 1980, as well as editing books for several other well-known Bible teachers including Dr. Lester Sumrall. In 1972 she began ministering regularly at her local church in Collinsville, Oklahoma. In 1980 she began traveling full time both nationally and internationally, with her focal points in Scandinavia and Europe. She has also ministered seven times in the Soviet Union.

After the homegoing of her husband in 1986, the Lord led Billye to study Hebrew in Israel. Working primarily through a Jewish ulpan (special language school), she takes Christians to Israel at least twice a year to see modern-day Israel through Jewish eyes. Bible prophecy is an important part of Billye's teaching. Billye is a frequent conference speaker (numerous times of Brother Kenneth Copeland's Believers Conventions) and ministers in churches, Bible schools, family camps, and on television. The emphasis of her ministry is on the Glory of God and His Glorious Church. She truly loves the Body of Christ and desires to see it become the Glorious Church Jesus promised to receive unto Himself.